K Roger Aoki Selected Research

Torticollis (Wryneck)

1/2017	Antibody responses to botulinum neurotoxin type A of toxin-treated spastic equinus children with cerebral palsy: A randomized clinical trial comparing two injection schedules.
4/2016	Submolecular recognition of the C-terminal domain of the heavy chain of botulinum neurotoxin type A by T cells from toxin-treated cervical dystonia patients.
4/2015	The C-terminal heavy-chain domain of botulinum neurotoxin a is not the only site that binds neurons, as the N-terminal heavy-chain domain also plays a very active role in toxin-cell binding and interactions.
7/2014	Reduction of established antibody responses against botulinum neurotoxin A by synthetic monomethoxypolyethylene glycol peptide conjugates.
9/2013	The rat Digit Abduction Score (DAS) assay: a physiological model for assessing botulinum neurotoxin-induced skeletal muscle paralysis.
1/2012	Molecular immune recognition of botulinum neurotoxin B. The light chain regions that bind human blocking antibodies from toxin-treated cervical dystonia patients. Antigenic structure of the entire BoNT/B molecule.
12/2011	Human T-cell responses to botulinum neurotoxin. Responses in vitro of lymphocytes from patients with cervical dystonia and/or other movement disorders treated with BoNT/A or BoNT/B.
7/2011	Regions of botulinum neurotoxin A light chain recognized by human anti-toxin antibodies from cervical dystonia patients immunoresistant to toxin treatment. The antigenic structure of the active toxin recognized by human antibodies.
6/2011	Reduction of antibody response against botulinum neurotoxin A by synthetic monomethoxypolyethylene glycol-peptide conjugates.
5/2011	Association of HLA Class II alleles and haplotypes with cervical dystonia: HLA DR13-DQ6 (DQB1*0604) homozygotes are at greatly increased risk of cervical dystonia in Caucasian Americans.

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K Roger Aoki Research Topics

Disease

14	Torticollis (Wryneck) 01/2017 - 03/2006
7	Paralysis (Palsy) 04/2015 - 01/2003
4	Pain (Aches) 10/2014 - 07/2003
3	Movement Disorders (Movement Disorder) 12/2011 - 11/2003
2	Muscle Spasticity (Spastic) 01/2017 - 12/2012
2	Cerebral Palsy (Spastic Diplegia) 01/2017 - 11/2003
2	Neuroblastoma 04/2015 - 01/2012
2	Migraine Disorders (Migraine) 10/2014 - 07/2003
2	Chronic Pain 11/2011 - 04/2009
2	Spasm (Spasms) 09/2010 - 07/2003
2	Botulism 12/2004 - 01/2003
1	Hypersensitivity (Allergy) 10/2014
1	Hyperhidrosis 09/2013
1	Blepharospasm 09/2013
1	Tetanus 12/2012
1	Neuralgia (Stump Neuralgia) 11/2011
1	Acute Pain 09/2010
1	Overactive Urinary Bladder (Overactive Bladder) 09/2010
1	Spinal Cord Injuries (Spinal Cord Injury) 05/2008
1	Hemorrhage 08/2005
1	Fissure in Ano (Anal Fissure) 02/2004
1	Dystonic Disorders (Writer's Cramp) 11/2003
1	Myofascial Pain Syndromes (Myofascial Pain Syndrome) 07/2003
1	Headache (Headaches) 07/2003

Drug/Important Bio-Agent (IBA)

17	incobotulinumtoxinA FDA Link 01/2017 - 01/2003
13	Botulinum Toxins (Botulinum Toxin)IBA 07/2014 - 01/2003
12	Type A Botulinum Toxins (Botox)FDA Link 01/2017 - 07/2003
5	AntibodiesIBA 04/2015 - 02/2007
3	SNARE Proteins (SNAREs)IBA 01/2013 - 01/2003
3	Proteins (Proteins, Gene)FDA Link 05/2012 - 12/2004
3	Blocking AntibodiesIBA 01/2012 - 09/2008
2	Peptides (Polypeptides)IBA 04/2015 - 08/2005
2	Peptide Hydrolases (Proteases)FDA Link 12/2012 - 05/2012
2	Tetanus ToxinIBA 12/2012 - 12/2011
2	Immune Sera (Antisera)IBA 07/2011 - 08/2005
2	Adenosine Triphosphate (ATP)IBA 09/2010 - 05/2008
1	Acetylcholine (Acetylcholine Chloride)FDA Link 04/2015
1	Ion Channels (Ion Channel)IBA 10/2014
1	Pharmaceutical PreparationsIBA 10/2014
1	amsonic acid (DAS)IBA 09/2013
1	Synaptosomal-Associated Protein 25IBA 01/2013
1	NeurotoxinsIBA 12/2012
1	Soluble N-Ethylmaleimide-Sensitive Factor Attachment ProteinsIBA 12/2012
1	NeuropeptidesIBA 11/2011
1	Neurotransmitter Agents (Neurotransmitter)IBA 11/2011
1	Purinergic Receptors (Receptors, Purine)IBA 09/2010
1	rimabotulinumtoxinB FDA Link 09/2008
1	botulinum toxin type EIBA 01/2007
1	ToxoidsIBA 03/2006
1	Biological ProductsIBA 03/2004
1	Analgesics (Analgesic Drugs)IBA 07/2003
1	R-SNARE Proteins (Vesicle-Associated Membrane Protein)IBA 01/2003

Therapy/Procedure

2	Therapeutics 04/2009 - 01/2003